Design evaluation and optimisation in crossover pharmacokinetic studies analysed by nonlinear mixed effects models
نویسندگان
چکیده
منابع مشابه
Design evaluation and optimisation in crossover pharmacokinetic studies analysed by nonlinear mixed effects models.
Bioequivalence or interaction trials are commonly studied in crossover design and can be analysed by nonlinear mixed effects models as an alternative to noncompartmental approach. We propose an extension of the population Fisher information matrix in nonlinear mixed effects models to design crossover pharmacokinetic trials, using a linearisation of the model around the random effect expectation...
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ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2011
ISSN: 0277-6715
DOI: 10.1002/sim.4390